The territory of the region belongs to two physiographical regions: The West Siberian Plain and Altay-Sayan highlands. The mountains occupy eastern and southern parts of the region, while the western and northern ones have campaign landscape.
The climate is severe, with long cold dry winters and hot, usually dry summers. The regions main waterway is the Ob River. The rivers of Biya, Katun, and Chuya are also important. The biggest lakes are Kulundinskoye, Kuchukskoye, and Mikhaylovskoye. The Altay Territory has huge reserves of raw materials, especial materials used for building, as well as significant mineral reserves. These include nonferrous metals, lead and iron ores, manganese, tungsten, molybdenum, bauxite, and gold. Forests cover about 60,000 km² of the region’s land.