You may get to/from Vologda Region by air, train or bus.
Air
There are regular flights to/from St. Petersburg’s Pulkovo-1 and Moscow’s Bykovo.
Train
There are at least 3 daily trains from Vologda to both Moscow (Yaroslavl Station) and St. Petersburg (Moscow Station).
Bus
The only long-distance service in and out of Vologda is a daily service to/from Yaroslavl and Ivanovo.