Add to favorite
 
123
Subscribe to our Newsletters Subscribe to our Newsletters Get Daily Updates RSS


New Anti-Epileptic Agent Discovered
March 31, 2009 17:01


Scientists from the Russian city of Novosibirsk currently work on developing new effective and cheap anticonvulsants, which are also less toxic than existing anti-epileptic drugs.

Patients with epilepsy desperately need effective and non-toxic treating agents. Researchers from Novosibirsk Institute of Organic Chemistry (Siberian branch of Russian Academy of Sciences) suggest making anticonvulsants, based on pinene amino acids. Scientists have already performed some pharmacology studies of the new drug on non-pedigree laboratory mice.

Statistics says that about 3 per cent of Earths population suffers from epileptic seizures to a greater or lesser degree. In order to prevent convulsions, doctors usually recommend their patients to take pharmaceuticals, containing gamma-aminobutyric acid. However, this kind of therapy is almost useless for about one fourth of epileptics. That is why doctors and scientists continue their search for anticonvulsants, which are more effective than existing ones and have as little side effects as possible.

Basic substances for such therapeutic agents can vary, and amino acid derivatives, for instance, which are produced from alpha-pinenes, fit perfectly, researchers from Novosibirsk think. Alpha-pinenes belong to hydrocarbons of terpene type and are among most common natural terpenes pine needle oil (turpentine) contains many of these chemical compounds, for example. Amino acids from alpha-pinenes have rigid structure and are more selective during binding with target molecules. During studies scientists also discovered that abovementioned chemical compounds showed higher biological activity than derivatives of gamma-aminobutyric acid.

Chemical
Chemical structure of alpha-pinene
Anticonvulsant activity of new possible therapeutic agents was tested on white non-pedigree mice, which received intraperitoneal injections of pentylenetetrazol and nicotine, which are well-known drugs, affecting nervous system and causing convulsions. Amino ester of an amino acid, belonging to alpha-pinenes, showed great anticonvulsant activity in 7-fold dilution compared to Phenobarbital, a common anticonvulsant agent. Moreover, this substance showed only a slight effect on general emotional state and motion behaviour. In addition, said amino ester causes no sleepiness and has moderate toxicity level.

Median lethal dose (LD50) of new possible anticonvulsant is 8.1 times less than that of Phenobarbital and exceeds 1000 mg (1 g) of the drug per one kilogram of body weight, when introduced intragastrically scientists claim you should eat a lot of this drug before it does you any harm.

All abovementioned properties of the amino ester and simple extraction technique (it contains only two stages) from a common substance alpha-pinene allow scientists to suggest this derivative becoming the basic substance for development of new almost non-toxic anticonvulsant agents, thus making life of epilepsy patients easier.

Source: Science & Technology

Kizilova Anna


Tags:      

Next Previous

You might also find interesting:

Cell Therapy to Fight Traumatic Coma Smoother Plexiglas Developed Transgenic Plants Grow in Moscow Region Chess Rebellion of the Machines: How Russian Robot Defeated Grandmasters Propellant-Consuming Bacteria









Comment on our site


RSS   twitter   facebook   submit

Bookmark and Share

search on the map
TAGS:
Moscow traffic  Festivals in Moscow  State Duma  Russian Duma  Russian laws  Incidents  Russian Cinema  Russian tourism  Russian regions  Exhibitions in Moscow  Events in Moscow  activity holidays  Sochi Airport  Evgeny Plyushchenko  Syria  Russian boxer  Flood in Khabarovsk   Gennady Troshkov  Exhibitions in Saint Petersburg  Theatre Festivals  handguns  Silver Necklace Of Russia  Russian opposition activists  Karelia   Amur Region  Mercedes-Benz Fashion Week Russia  Rock Music  Natalya Osipova  Feodor Bruni  Russian Antiquity  Moscow  Exhibitions in St. Petersburg  Russian business  Moscow Archeology Museum  Novozavidovsky  Russian Animation  Russian rouble  Vladimir Vysotsky  Safari Park of Gelendzhik  Dimitrovgrad  Russian transport  Musicals in Moscow  travel to Russia  Giulio Di Sabato  Bashkiria  St. Petersburg  Arkhangelsk  Novgorod Region  Pavlov Posad  Pavel Sukhoy 


Travel Blogs
Top Traveling Sites